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Happy clients. Ready to see the impact? An article by Ed Yong about our work on the spatial organization of the plaque microbiome is here.
The human oral microbiome consists of more than bacterial species. Within the structure, individual taxa are localized at the micron scale in ways suggestive of their functional niche in the consortium.
https://baydracfepro.tk The hedgehog consortium illustrates how complex structural organization can emerge from micron-scale interactions of the constituent organisms. Publications Biogeography of a human oral microbiome at the micron scale. Systems-level analysis of microbial community organization through combinatorial labeling and spectral imaging.
To extract the maximum information from ribosomal RNA tag sequencing data, we are using an innovative, information-theory based approach called oligotyping developed by our colleague A. Murat Eren. Oligotyping, and the related Minimum Entropy Decomposition, allow us to partition sequencing data with single-nucleotide resolution.
Using this method we are investigating the distribution patterns of species-level taxa in the oral microbiome. We discovered very closely related organisms with dramatically different distributions across oral sites, suggesting a level of ecological and functional biodiversity not previously recognized. An article by Carl Zimmer about our work on oligotyping the oral microbiome is here.
Publications Oligotyping analysis of the human oral microbiome.
Dynamics of tongue microbial communities with single-nucleotide resolution using oligotyping. We are also investigating the microbes of the gut, using a mouse model.
By examining thin sections of small intestine, large intestine, and cecum, we are studying the distribution of 15 bacterial taxa as a first step in understanding the functional roles of these bacteria in mammalian digestion, metabolism, and immune system function. Viviana Morillo Lopez Postdoctoral Scientist e: vmorillo mbl.
The Bay Paul Center. Mark Welch, J.
Image credit: Jessica Mark Welch et al. Using Spatial Structure to Understand Microbial Community Function Bacteria play a critical role in both human health and the functioning of healthy ecosystems.
Image credit: Jessica Mark Welch.